University of Michigan (Professor and Associate Chair of Faculty Leadership, Department of Human Genetics, University of Michigan; 75 publications in PubMed)
The Robins lab studies hormonal regulation of gene expression in cell and mouse models. Our main focus is the role of androgen receptor (AR) in prostate cancer initiation, progression and response to therapy. We have found selective modulators to inhibit AR regulation of genes that drive cancer but not normal cell growth, and act via distinct androgen response elements. This selective effect may slow tumor growth and delay resistance to treatment. We also study sex differences in gene expression exerted by KRAB-ZFP repressors that are epigenetic in mechanism and independent of steroids. With over 400 KRAB-ZFPs in the human genome, these regulators have key roles in metabolism, reproduction and evolution.