(Professor and Associate Vice Chair, Cellular and Molecular Pharmacology, Herzstein Distinguished Investigator, University of California, San Francisco; 134 publications in PubMed).
The two main research themes in the Ingraham Lab are sex-dependent central regulation of female metabolism and physiology, and regulation of nuclear receptors by lipid ligands. Within these themes, the Ingraham Lab is broadly interested in how the female brain uniquely controls a wide-range of sex-specific physiological responses. Mouse models coupled with genomics and pharmacogenetics are leveraged to define the estrogen-sensitive neuronal modules important in locomotion, thermogenesis, reproduction and bone density. This research theme is highly relevant to age-related diseases in hormone deficient stages and to women’s health. With regard to lipid regulation of nuclear receptors, current research focuses on NR5A nuclear receptors, SF-1 and LRH-1 in two model systems, the liver hepatocyte, and the mouse or human intestinal organoid. Efforts are underway to find synthetic ligands that could prove useful in fatty liver disease and inflammatory bowel disease.